Leacky Muchene

• • Fully independently support the statistics needs of the HMPV, Influenza, HIV and SARS‑CoV‑2 (COVID‑19) pre‑clinical research teams.

• • Performs bioassay qualification to assess linearity, intra and inter‑assay precision amongst others, while following Food and Drug Administration (FDA) guidelines, thereby ensuring that resulting titers can be relied upon in the pre‑clinical and clinical development phases.

• • Actively involved in design of animal experiments (mice, rats, hamsters, ferrets and non‑human primates). I provide sample size/power calcu‑ lations, suggest statistical analyses methods and write the statistical analysis plans.

• • Performs analyses of animal experiments using parametric methodology such as Tobit regression and cumulative logistic regression and non‑ parametric methods such as Wilcoxon rank sum and Cochran–Mantel–Haenszel tests.

• • Develops R Shiny applications for routine analyses such as bioassay titer computation. This has provided scientists with independence in cal‑ culating the reportable values for their samples without relying on statisticians. Further, the turnaround time for scientific reporting, laboratory‑ related error detection and remedy has greatly improved for the scientists.

• • Performs research into methodological developments with potential to improve statistical efficiency and accuracy of reported results, for in‑

StatsDecideAnalytics and Consulting Limited

stance robust methods for non‑linear curve fitting and outlier detection.

• • As the owner and vision bearer of the organization, I provide leadership and supervision to the team of consultants (support staff) when engaged in various projects.

• • Actively engages with potential clients to sensitize them on the benefits of statistics to their organization and the services we can provide therein.

• • Being the team leader, I ensure that client expectations on projects are met within agreed timelines and budget by prioritizing on team expertise and efficiency.

• • I am actively engaged in routine statistical analysis and reporting of client projects.

REMOTE STATiSTiCiAN

◦ • Consulting contract statistician for diverse clients both in academia, non‑ governmental organizations and private sector in Kenya.

◦ • My main tasks were to propose appropriate statistical approaches to address client hypotheses and implement the analysis plans.

◦ • Engaged with clients to understand their operations and evaluate statistical needs for which I positively contributed to their satisfaction.

◦ • Provided training to individual clients on with TEX

• • Performed research in the context of pre‑clinical models for Alzheimer disease, culminating in a Ph.D thesis titled: "Statistical modelling in non‑ clinical pharmaceutical research".

• • I performed statistical analyses to evaluate the suitability of magnetic resonance imaging parameters as biomarkers for Alzheimer disease in neurodevelopment and neurodegeneration.

• • I extended the methodology for Bayesian variable selection in dose‑response modelling to correlated data from parallel and cross‑over dose‑ response studies.

• • During my tenure, I routinely performed statistical consultancy projects for various clients in both academia and industry (food and pharma‑ ceutical).

• • Notable achievements include several scientific publications in peer‑reviewedjournals and contributing as a chapter author in a book we pub‑ lished.